3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGR) Inhibitor Screening Kit
SKU: BTL-EL-AK-02084 |
Brand: Elabscience
Product Description
| Cat Number | E-BC-D011_48T |
|---|---|
| Category | Cell Metabolism Assay Kit |
| Pack Size | 48T |
| Detection Method | Colorimetric method |
| Research Field | Glycolysis and Lipid Metabolism;Inhibitor Screening |
| Sample Type | Inhibitor |
| Assay Length | 40 min |
| Reader | Microplate reader |
| Test Principle | 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is the rate-limiting enzyme of mevalonate pathway, which is the metabolic pathway of acetyl-CoA to produce cholesterol.This detection kit can screen inhibitors of HMGR, which is an important tool for basic research of cholesterol and other related metabolic pathways.<br/> The detection principle of this kit: HMGR catalyzed substrate reaction consumes NADPH, and the absorbance decreases at 340 nm. The addition of inhibitors will inhibit HMGR enzyme activity, resulting in a decrease in the rate of absorbance decline. The inhibition rate can be calculated by measuring the change value of absorbance. |
| Storage | This product can be stored at -20°C for 12 months with shading light. |
| Technical Manual | View Document |
| Msds | View Document |
| Product Url | View Document |
| Note | The product is for research use only |
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