Product Description
| Cat Number | HY-N8504 |
|---|---|
| Category | Biochemical Assay Reagent |
| Pack Size | 1 EA |
| Description | Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs ( IC 50 =13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells ( IC 50 =1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells ( IC 50 s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus. |
| Molecular Weight | 477.55 |
| Research Field | Infection |
| Formula | C28H31NO6 |
| Smiles | CC(C1=O)=C([C@@](OC/2)([H])CC2=C\C(C)=C\C(C)=C\C(C)=C\C(C=C3)=CC=C3[N+]([O-])=O)OC(OC)=C1C |
| Scientific Background | Anti-infection |
| View Document | |
| Note | The product is for research use only |
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