Product Description
| Cat Number | HY-12323G |
|---|---|
| Category | GMP Small Molecule |
| Pack Size | 1 EA |
| Description | ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca 2+ influx through both voltage-gated Ca 2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) [1] [2] [3] . In Vitro: ISX-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression [1] . Molecular exploration of ISX-9-induced regulation of neurogenesis (via FACS and microarray of SGZ stem and progenitor cells) suggested the involvement of the myocyte-enhancer family of proteins (Mef2) [1] . In Vivo: ISX-9 (20 mg/kg; for 12 days; mice) treatment improves hippocampal function. ISX-9 enhances spatial memory ability in the Morris water maze test. ISX-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2 [1] . |
| Molecular Weight | 234.27 |
| Research Field | Neurological Disease; Cardiovascular Disease |
| Formula | C11H10N2O2S |
| Smiles | O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3 |
| Scientific Background | Membrane Transporter/Ion Channel;Neuronal Signaling |
| View Document | |
| Note | The product is for research use only |
Share Item: