Product Description
| Cat Number | HY-10320G |
|---|---|
| Category | GMP Small Molecule |
| Pack Size | 1 EA |
| Description | Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC 50 s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity [1] . |
| Molecular Weight | 527.66 |
| Research Field | Cancer |
| Formula | C31H37N5O3 |
| Smiles | O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3 |
| Scientific Background | MAPK/ERK Pathway |
| View Document | |
| Note | The product is for research use only |
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