Product Description
| Cat Number | HY-W777360 |
|---|---|
| Category | Isotope-Labeled Compounds |
| Pack Size | 1 EA |
| Description | Harman- 13 C 2 , 15 N is 13 C and 15 N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor ( IC 50 =7 μM), with IC 50 values for mACh , Opioid Receptor , MAO-A/B , and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin , with IC 50 values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor ( IC 50 =30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) [1] [2] [3] [4] [5] [6] . |
| Molecular Weight | 185.20 |
| Research Field | Inflammation/Immunology;Neurological Disease |
| Formula | C10 13C2H10N 15N |
| Smiles | CC1=[15N][13CH]=[13CH]C2=C1NC3=C2C=CC=C3 |
| Scientific Background | GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling;Others |
| View Document | |
| Note | The product is for research use only |
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